4.7 Article

An antibody-graphene oxide nanoribbon conjugate as a surface enhanced laser desorption/ionization probe with high sensitivity and selectivity

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 22, Pages 4619-4622

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc10401c

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Funding

  1. Strategic Priority Research Program of the Chinese Academy of Sciences [XDB14010400]
  2. National Natural Science Foundation of China [21107120, 21377141, 21422509, 21107036]
  3. Excellent Young Scientist Grant of the Chinese Academy of Sciences

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Graphene oxide nanoribbons (GONRs) were covalently functionalized with an antibody using polyethylene glycol (PEG) as a linker to produce a novel probe for surface enhanced laser desorption/ionization mass spectrometry (SELDI MS). This probe provides a highly sensitive and selective platform for enrichment and MS detection of small molecules in complex media.

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