Journal
MATRIX BIOLOGY
Volume 52-54, Issue -, Pages 176-190Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matbio.2016.02.009
Keywords
Osteoclast; Integrin; Bone matrix; Bone resorption
Categories
Funding
- European Commission [295181, 602300]
- Telethon [GGP14014]
- Italian Association for Cancer Research [IG 12713, IG 11950]
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Osteoclasts are unique cells that destroy the mineralized matrix of the skeleton. There is a love-hate relationship between the osteoclasts and the bone matrix, whereby the osteoclast is stimulated by the contact with the matrix but, at the same time, it disrupts the matrix, which, in turn, counteracts this disruption by some of its components. The balance between these concerted events brings about bone resorption to be controlled and to contribute to bone tissue integrity and skeletal health. The matrix components released by osteoclasts are also involved in the local regulation of other bone cells and in the systemic control of organismal homeostasis. Disruption of this regulatory loop causes bone diseases, which may end up with either reduced or increased bone mass, often associated with poor bone quality. Expanding the knowledge on osteoclast-to-matrix interaction could help to counteract these diseases and improve the human bone health. In this article, we will present evidence of the physical, molecular and regulatory relationships between the osteoclasts and the mineralized matrix, discussing the underlying mechanisms as well as their pathologic alterations and potential targeting. (C) 2016 Elsevier B.V. All rights reserved.
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