Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 3, Pages 584-587Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08129c
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Funding
- Instruct RD Pilot Project
- ESFRI Instruct Core Centre CERM - Italy
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An integrated approach which combines in-cell NMR spectroscopy with optical and X-ray fluorescence microscopy was developed to describe the intracellular maturation state of human Cu, Zn-SOD1. Microscopy data show a correlation between the intracellular levels of SOD1 and the content of zinc, corresponding to zinc binding to SOD1 observed by in-cell NMR.
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