Plant-derived peptides for the improvement of Alzheimer's disease: Production, functions, and mechanisms

Alzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset that seriously affects human health. Plant-derived peptides have been found to hinder the development of AD pathologies, which is an excellent candidate for preventing AD. However, due to the excessively complicated pathogenesis of AD and the fact that most studies on the activity of plant-derived peptides are single and not deep enough, which restricted the development and application of plant-derived AD-prevention peptides (PADPs). This review summarized the currently available means of obtaining PADPs, in vitro and in vivo AD-prevention activity validation protocols, molecular pathways of PADPs, the structure-activity relationship between plant-derived peptides and AD-prevention activity, and some perspectives of current advanced technologies. This paper will help to develop the foundation for the production and exploitation of PADPs.

Automated summary

Alzheimer's disease (AD) is a progressive neurodegenerative disease that seriously affects human health. Plant-derived peptides have shown potential in preventing AD, but the complex pathogenesis of AD and limited research on the activity of these peptides have hindered their development and application. This review provides a comprehensive summary of obtaining plant-derived AD-prevention peptides, validation protocols for their activity, molecular pathways involved, structure-activity relationship, and future perspectives. The findings presented in this paper will help advance the production and exploitation of plant-derived AD-prevention peptides.