Journal
MEDCOMM
Volume 4, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/mco2.265
Keywords
cancer therapy; combination therapy; drug resistance; resensitization
Categories
Ask authors/readers for more resources
Resistance to cancer therapies is a major cause of treatment failure and poor patient survival, and can be caused by various factors including genetics, epigenetics, and the tumor microenvironment. Numerous mechanisms of drug resistance have been discovered, and strategies to overcome resistance include identifying biomarkers, developing new targets and drugs, combination therapies, and modulating the tumor microenvironment. This article provides an overview of the mechanisms of drug resistance in cancer and the latest tackling approaches, as well as future perspectives on polytherapy, nanoparticle delivery systems, and advanced drug design tools.
Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can arise from genetic, epigenetic, and microenvironmental factors. Various mechanisms have been discovered and extensively studied, including drug inactivation, reduced intracellular drug accumulation by reduced uptake or increased efflux, drug target alteration, activation of compensatory pathways for cell survival, regulation of DNA repair and cell death, tumor plasticity, and the regulation from tumor microenvironments (TMEs). To overcome cancer resistance, a variety of strategies have been proposed, which are designed to enhance the effectiveness of cancer treatment or reduce drug resistance. These include identifying biomarkers that can predict drug response and resistance, identifying new targets, developing new targeted drugs, combination therapies targeting multiple signaling pathways, and modulating the TME. The present article focuses on the different mechanisms of drug resistance in cancer and the corresponding tackling approaches with recent updates. Perspectives on polytherapy targeting multiple resistance mechanisms, novel nanoparticle delivery systems, and advanced drug design tools for overcoming resistance are also reviewed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available