Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis

Article Multidisciplinary Sciences

Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression

Andrea Comba et al.

Summary: This study investigates the dynamic anatomical structures called oncostreams in high grade gliomas (HGG) and their regulation by COL1A1. The researchers found that oncostreams play a role in tumor growth and aggression, facilitating the distribution of tumor and non-tumor cells within the tumor and potentially contributing to the invasion of normal brain tissue. They also discovered that COL1A1 is a central gene in the organization of oncostreams and a powerful regulator of glioma malignant behavior. Inhibiting COL1A1 can eliminate oncostreams and alter the tumor microenvironment, leading to reduced expression of mesenchymal associated genes and extended survival in animal models.

NATURE COMMUNICATIONS (2022)

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Article Oncology

Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses

Andrea Comba et al.

NEURO-ONCOLOGY (2020)

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Article Cell Biology

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

Felipe J. Nunez et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Cell Biology

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

Carl Koschmann et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Article Multidisciplinary Sciences

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

Anda-Alexandra Calinescu et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

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Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis

Related references

Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression

Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses

IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

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