Exploring the Reactivity of Polyoxometalates toward Proteins: From Interactions to Mechanistic Insights

The latest advances in the study of the reactivity of metal-oxo clusters toward proteins showcase how fundamental insights obtained so far open new opportunities in biotechnology and medicine. In this Perspective, these studies are discussed through the lens of the reactivity of a family of soluble anionic metal-oxo nanoclusters known as polyoxometalates (POMs). POMs act as catalysts in a wide range of reactions with several different types of biomolecules and have promising therapeutic applications due to their antiviral, antibacterial, and antitumor activities. However, the lack of a detailed understanding of the mechanisms behind biochemically relevant reactions-particularly with complex biological systems such as proteins-still hinders further developments. Hence, in this Perspective, special attention is given to reactions of POMs with peptides and proteins showcasing a molecular-level understanding of the reaction mechanism. In doing so, we aim to highlight both existing limitations and promising directions of future research on the reactivity of metal-oxo clusters toward proteins and beyond.

Automated summary

This Perspective discusses the reactivity of polyoxometalates (POMs), a family of soluble anionic metal-oxo nanoclusters, towards proteins. POMs serve as catalysts in various reactions and have potential therapeutic applications. However, the lack of detailed understanding of the reaction mechanisms, especially with complex biological systems like proteins, hinders further developments. The reactions of POMs with peptides and proteins are highlighted to provide a molecular-level understanding of the reaction mechanism.