Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of O-1(2) upon irradiation, potent photo-toxicity as well as low cytotoxicity in the off-state.