Competitive exclusion principle among synthetic non-biochemical protocells

Essential for Darwin's struggle for existence,the competitive exclusion principle (CEP) states that any two species occupying the same niche will compete with each other to the detriment of one of the species, which will thus be excluded.Here, we report on competition experiments between two populations of autono-mous, artificial, self-booting, self-reproducing polymer-based pro-tocells emerging from a homogeneous blend of small synthetic chemicals in a one-pot reactor using polymerization-induced self -as-sembly (PISA). These protocells are carbon chemistry based but biochemistry free. The populations share their environment, differing only in that one contains a photocatalyst that confers ad-vantages in reproduction. Competition in the shared environment follows the CEP. Thus, biochemistry is sufficient, not necessary, to drive the CEP. This has implications for protocell research, the origin and early evolution of life, and the laboratory synthesis of life and also relaxes constraints for the potential presence and evolution of generalized life in exoplanets.

Automated summary

The competitive exclusion principle states that two species occupying the same niche will compete with each other, leading to the exclusion of one species. We conducted competition experiments between two populations of artificial protocells and found that competition still occurs even without biochemical functionality. This has significant implications for protocell research, the origin and early evolution of life, and the laboratory synthesis of life, as well as the potential presence and evolution of generalized life in exoplanets.