From bugs to drugs: Bacterial 3-IAA enhances efficacy of chemotherapy in pancreatic cancer

Tintelnot et al.1 identified enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, as a predictor of chemotherapy response in pancreatic adenocarcinoma. Recapitu-lated in mouse models, 3-IAA represents a novel potential therapeutic approach for chemotherapy sensitization.

Automated summary

Tintelnot et al. found that enrichment of indole-3-acetic acid (3-IAA), a tryptophan metabolite produced by gut microbiota, can predict the response of pancreatic adenocarcinoma to chemotherapy. Recapitulated in mouse models, 3-IAA represents a potential novel therapeutic approach for chemotherapy sensitization.