Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 92, Pages 16479-16482Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc04958j
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Funding
- Research Grants Council of Hong Kong [705310P, 704612P, 703913P]
- Livzon Pharmaceutical Group
- University of Hong Kong
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Over 300 Bi-binding peptides from 166 proteins in H. pylori were identified by Bi-IMAC. Bi3+ exhibits high selectivity towards peptide enriched by cysteines and histidines with dominated motif patterns of CXnC, CXnH and HXnH. Structural rationalization and functional categorization on the identified Bi-binding peptides and proteins provide an insight into the inhibitory action of bismuth drugs.
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