Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 82, Pages 15180-15183Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05890b
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Funding
- National Institutes of Health [GM084933]
- Molecular Basis of Disease Program (MBD) at GSU
- Graduate Assistance in Areas of National Need (GAANN) Fellowship at GSU
- Frontier Scientific Inc.
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The feasibility of a neighboring boronic acid-facilitated facile condensation of an aldehyde is described. This reaction is bio-orthogonal, complete at room temperature within minutes, and suitable for bioconjugation chemistry. The boronic acid group serves the dual purpose of catalyzing the condensation reaction and being a handle for secondary functionalization.
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