Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 78, Pages 14624-14627Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc06325f
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Funding
- National Institutes of Health [R01-CA83831, P20-GM103638]
- University of Kansas Cancer Center
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Mammalian cells acquire cholesterol, a critical membrane constituent, through multiple mechanisms. We synthesized mimics of cholesterol, fluorescent N-alkyl-3 beta-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor-mediated uptake pathway.
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