Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 45, Pages 9332-9335Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02259b
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Funding
- Centre of Excellence in Medical Engineering Centre - Wellcome Trust
- EPSRC [WT088641/Z/09/Z]
- Kings College London and UCL Comprehensive Cancer Imaging Centre - CRUK
- MRC (England)
- DoH (England)
- National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London
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Magnetic and fluorescent hydroxyapatite nanoparticles were synthesised using Al(OH)(3)-stabilised MnFe2O4 or Fe3O4 nanoparticles as precursors. They were readily and efficiently radiolabelled with F-18. Bisphosphonate polyethylene glycol polymers were utilised to endow the nanoparticles with excellent colloidal stability in water and to incorporate cyclam for high affinity labelling with Cu-64.
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