Journal
ACS APPLIED BIO MATERIALS
Volume 6, Issue 6, Pages 2102-2110Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.2c00771
Keywords
polycarbonate; polylactide; trehalose; nanoparticle; amyloid beta; Alzheimer's
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Trehalose-conjugated polycarbonate-co-lactide nanoparticles have the ability to inhibit protein aggregation and activate cellular autophagy, making them a potential treatment for neurodegenerative diseases.
Trehalose is a disaccharide that is capable of inhibitingproteinaggregation and activating cellular autophagy. It has been shown thata polymer or nanoparticle form, terminated with multiple trehaloseunits, can significantly enhance the anti-amyloidogenic performanceand is suitable for the treatment of neurodegenerative diseases. Here,we report a trehalose-conjugated polycarbonate-co-lactide polymer and formulation of its nanoparticles having multiplenumbers of trehalose exposed on the surface. The resultant poly-(trehalose)nanoparticle inhibits the aggregation of amyloid beta peptides anddisintegrates matured amyloid fibrils into smaller fragments. Moreover,the poly-(trehalose) nanoparticle lowers extracellular amyloid beta oligomer-driven cellular stress and enhances cell viability. The presenceof biodegradable polycarbonate components in the poly-(trehalose) nanoparticlewould enhance their application potential as an anti-amyloidogenicmaterial.
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