Biodegradable Poly(trehalose) Nanoparticle for Preventing Amyloid Beta Aggregation and Related Neurotoxicity

Trehalose is a disaccharide that is capable of inhibitingproteinaggregation and activating cellular autophagy. It has been shown thata polymer or nanoparticle form, terminated with multiple trehaloseunits, can significantly enhance the anti-amyloidogenic performanceand is suitable for the treatment of neurodegenerative diseases. Here,we report a trehalose-conjugated polycarbonate-co-lactide polymer and formulation of its nanoparticles having multiplenumbers of trehalose exposed on the surface. The resultant poly-(trehalose)nanoparticle inhibits the aggregation of amyloid beta peptides anddisintegrates matured amyloid fibrils into smaller fragments. Moreover,the poly-(trehalose) nanoparticle lowers extracellular amyloid beta oligomer-driven cellular stress and enhances cell viability. The presenceof biodegradable polycarbonate components in the poly-(trehalose) nanoparticlewould enhance their application potential as an anti-amyloidogenicmaterial.

Automated summary

Trehalose-conjugated polycarbonate-co-lactide nanoparticles have the ability to inhibit protein aggregation and activate cellular autophagy, making them a potential treatment for neurodegenerative diseases.