Spatial Dependence of Log-Transformed Electromyography-Force Relation: Model-Based Sensitivity Analysis and Experimental Study of Biceps Brachii

This study investigated electromyography (EMG)-force relations using both simulated and experimental approaches. A motor neuron pool model was first implemented to simulate EMG-force signals, focusing on three different conditions that test the effects of small or large motor units located more or less superficially in the muscle. It was found that the patterns of the EMG-force relations varied significantly across the simulated conditions, quantified by the slope (b) of the log-transformed EMG-force relation. b was significantly higher for large motor units, which were preferentially located superficially rather than for random depth or deep depth conditions (p < 0.001). The log-transformed EMG-force relations in the biceps brachii muscles of nine healthy subjects were examined using a high-density surface EMG. The slope (b) distribution of the relation across the electrode array showed a spatial dependence; b in the proximal region was significantly larger than the distal region, whereas b was not different between the lateral and medial regions. The findings of this study provide evidence that the log-transformed EMG-force relations are sensitive to different motor unit spatial distributions. The slope (b) of this relation may prove to be a useful adjunct measure in the investigation of muscle or motor unit changes associated with disease, injury, or aging.

Automated summary

This study examined electromyography (EMG)-force relations using both simulated and experimental approaches. Simulations showed significant variations in the EMG-force relations, depending on the size and location of motor units in the muscle. Experimental analysis of the biceps brachii muscles of healthy individuals confirmed spatial dependence of the log-transformed EMG-force relations. The findings suggest that the slope (b) of the log-transformed EMG-force relation could serve as a valuable measure for investigating muscle or motor unit changes associated with disease, injury, or aging.