Co(III) Intermediates in Cobalt-Catalyzed, Bidentate Chelation Assisted C(sp2)-H Functionalizations

The C-H bond activation and functionalization is a powerful tool that provides efficient access to various organic molecules. The cobalt-catalyzed oxidative C-H bond activation and functionalization has earned enormous interest over the past two decades. Since then, a wide diversity of synthetic protocols have been published for C-C, C-Het, and C-Hal bond formation reactions. To gain some insights into the reaction mechanism, the authors performed a series of experiments and collected evidence. Several groups have successfully isolated reactive Co(III) intermediates to elucidate the reaction mechanism. In this review, we will summarize information concerning the isolated and synthesized Co(III) intermediates in cobalt-catalyzed, bidentate chelation assisted C-H bond functionalization and their reactivity based on the current knowledge about the general reaction mechanism.

Automated summary

C-H bond activation and functionalization is a powerful tool for accessing various organic molecules efficiently. The cobalt-catalyzed oxidative C-H bond activation and functionalization has gained significant interest in the past two decades and various synthetic protocols for C-C, C-Het, and C-Hal bond formation reactions have been published. The authors conducted experiments and collected evidence to gain insights into the reaction mechanism, successfully isolating reactive Co(III) intermediates. This review summarizes the current knowledge regarding isolated and synthesized Co(III) intermediates in cobalt-catalyzed, bidentate chelation assisted C-H bond functionalization and their reactivity.