Journal
INORGANICS
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/inorganics11040154
Keywords
bentonite; curcumin; zinc metal; pillaring; antioxidant; anti-diabetes
Categories
Ask authors/readers for more resources
A green zinc-metal-pillared bentonite mediated curcumin extract (Zn@CN/BE) was synthesized as an enhanced antioxidant and antidiabetic agent with remarkable activities. The structure exhibited higher antioxidant and inhibition activities compared to individual components and commercial drugs. The enhancement effect was attributed to the zinc pillaring process, which improved the stability, dispersion, and solubility of the active compounds.
Green zinc-metal-pillared bentonite mediated curcumin extract (Zn@CN/BE) was synthesized and characterized as a low-cost and multifunctional (curcumin-based phytochemicals, zinc-capped curcumin, zinc/curcumin complexes, and zinc-pillared bentonite) antioxidant and antidiabetic agent with enhanced activity. The activities of the Zn@CN/BE structure were assessed in comparison with curcumin and ZnO as individual components and in the presence of miglitol and acarbose commercial drugs as controls. The structure validated remarkable antioxidant activities against the common oxidizing radicals (nitric oxide (94.7 +/- 1.83%), DPPH (96.4 +/- 1.63%), ABTS (92.8 +/- 1.33%), and superoxide (62.3 +/- 1.63 %)) and inhibition activities against the main oxidizing enzymes (porcine alpha-amylase (89.3 +/- 1.13%), murine alpha-amylase (70.8 +/- 1.54%), pancreatic alpha-Glucosidase (99.3 +/- 1.23%), intestinal alpha-Glucosidase (97.7 +/- 1.24%), and amyloglucosidase (98.4 +/- 1.64%)). The reported activities are higher than the activities of individual components and the studied ascorbic acid as well as the commercial drugs. This enhancement effect was assigned to the impact of the zinc pillaring process within the curcumin/bentonite host, which induced the stability, dispersions, and interactive interface of the essential active compounds in addition to the solubility and release rate of the intercalated curcumin extract. This paper recommends the application of the Zn@CN/BE structure as an enhanced, low-cost, biocompatible, safe, and simply produced antioxidant and antidiabetic agent.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available