Nanomaterials for Periodontal Tissue Regeneration: Progress, Challenges and Future Perspectives

Bioactive nanomaterials are increasingly being applied in oral health research. Specifically, they have shown great potential for periodontal tissue regeneration and have substantially improved oral health in translational and clinical applications. However, their limitations and side effects still need to be explored and elucidated. This article aims to review the recent advancements in nanomaterials applied for periodontal tissue regeneration and to discuss future research directions in this field, especially focusing on research using nanomaterials to improve oral health. The biomimetic and physiochemical properties of nanomaterials such as metals and polymer composites are described in detail, including their effects on the regeneration of alveolar bone, periodontal ligament, cementum and gingiva. Finally, the biomedical safety issues of their application as regenerative materials are updated, with a discussion about their complications and future perspectives. Although the applications of bioactive nanomaterials in the oral cavity are still at an initial stage, and pose numerous challenges, recent research suggests that they are a promising alternative in periodontal tissue regeneration.

Automated summary

Bioactive nanomaterials have great potential in periodontal tissue regeneration and have improved oral health in translational and clinical applications. This article reviews recent advancements in nanomaterials for periodontal tissue regeneration and discusses future research directions, focusing on improving oral health. Biomimetic and physiochemical properties of nanomaterials are described, including their effects on alveolar bone, periodontal ligament, cementum, and gingiva regeneration. The safety issues and potential complications of using nanomaterials as regenerative materials are also discussed.