Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 38, Pages 8048-8050Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02252e
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Funding
- Cancer Research UK Programme
- BBSRC [BB/K018043/1]
- EPSRC [EP/K039520/1]
- Biotechnology and Biological Sciences Research Council [BB/K018043/1] Funding Source: researchfish
- Cancer Research UK [11961, 18618] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K039520/1] Funding Source: researchfish
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A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-tetrads of a model genomic G4 structure.
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