4.7 Article

Polypyrrole nanoprobes with low non-specific protein adsorption for intracellular mRNA detection and photothermal therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 31, Pages 6800-6803

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01129a

Keywords

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Funding

  1. National Basic Research Program of China [2010CB732403]
  2. National Natural Science Foundation of China [21125524, 21475026, 21305016]
  3. Program for Changjiang Scholars and Innovative Research Team in University [IRT1116]

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In this work, we discovered that polypyrrole nanoparticles (PPy NPs) displayed a low non-specific protein adsorption. We herein present the first PPy NP-based biosensing platform for intracellular mRNA detection in living cells. We also demonstrate that PPy NPs exhibit high NIR absorbance and can be utilized for cancer photothermal therapy.

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