Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 25, Pages 5425-5428Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc08145e
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Funding
- NIGMS [R00GM092970]
- University of Oregon (UO)
- NSF/ARRA [CHE-0923589]
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D-Amino acid oxidase (DAO) plays important roles in regulating D-amino acid neurotransmitters and was recently identified as a key enzyme integral to hydrogen sulfide production from D-Cys. We report here the development of a simple biocompatible, bioluminescent method for measuring DAO activity based on the highly selective condensation of D-Cys with 6-hydroxy-2-cyanobenzothiazole (CBT-OH) to form D-luciferin.
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