Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 19, Pages 3993-3996Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc10204e
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Funding
- European Commission
- FCT Portugal (FCT Investigator)
- EPSRC
- EPSRC [EP/M003647/1] Funding Source: UKRI
- MRC [MC_PC_14116] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/M003647/1] Funding Source: researchfish
- Medical Research Council [MC_PC_14116] Funding Source: researchfish
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We report the design and synthesis of an aquacarbonyl Ru(II) dication cis-[Ru(CO)(2)(H2O)(4)](2+) reagent for histidine (His)-selective metallation of interleukin (IL)-8 at site 33. The artificial, non-toxic interleukin (IL)-8-Ru-II(CO)(2) metalloprotein retained IL-8-dependent neutrophil chemotactic activity and was shown to spontaneously release CO in live cells.
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