Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 62, Issue -, Pages 823-834Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.01.078
Keywords
Poly(L-lactic-co-glycolic acid); Tussah silk; Graphene oxide; Biocompatibility; Osteogenesis; Bone tissue engineering
Categories
Funding
- National Natural Science Foundation of China [51203196, U1204510]
- Program for Science &Technology Innovation Talents in Universities of Henan Province of China [15HASTIT024]
- Zhengzhou Science and Technology Program [141PPTGG400, 131PLJRC653]
- Key Science and Technology Research Program of Education Department of Henan province of China [14A540003, 14A540006]
Ask authors/readers for more resources
To engineer bone tissue, it is necessary to provide a biocompatible, mechanically robust scaffold. In this study, we fabricated an ultrafine nanofiber scaffold by electrospinning a blend of poly(L-lactic-co-glycolic acid), tussah silk fibroin, and graphene oxide (GO) and characterized its morphology, biocompatibility, mechanical properties, and biological activity. The data indicate that incorporation of 10 wt.% tussah silk and 1 wt.% graphene oxide into poly(L-lactic-co-glycolic acid) nanofibers significantly decreased the fiber diameter from 280 to 130 nm. Furthermore, tussah silk and graphene oxide boosted the Young's modulus and tensile strength by nearly 4-fold and 3-fold, respectively, and significantly enhanced adhesion, proliferation in mouse mesenchymal stem cells and functionally promoted biomineralization-relevant alkaline phosphatase (ALP) and mineral deposition. The results indicate that composite nanofibers could be excellent and versatile scaffolds for bone tissue engineering. (C) 2016 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available