Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 64, Issue -, Pages 318-328Publisher
ELSEVIER
DOI: 10.1016/j.msec.2016.03.086
Keywords
Anti-inflammatory; Antioxidant; Methacrylic polymer; Phytoalexin; Platelet aggregation
Categories
Funding
- CAPES/Brazil [DS12542]
- Fundacao Araucaria/Brazil [237/2014]
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This paper aimed to obtain new spray-dried microparticles containing ferulic acid (FA) prepared by using a tnethacrylic polymer (Eudragit (R) L100). Microparticles were intended for oral use in order to provide a controlled release, and improved in vitro and in vivo biological effects. FA-loaded Eudragit (R) L100 microparticles were obtained by spray-drying. Physicochemical properties, in vitro cell-based effects, and in vivo platelet aggregation were investigated. FA-loaded Eudragit (R) L100 microparticles were successfully prepared by spray-drying. Formulations showed suitable encapsulation efficiency, i.e. close to 100%. Microparticles were of spherical and almost-spherical shape with a smooth surface and a mean diameter between 2 and 3 mu m. Fourier-transformed infrared spectra demonstrated no chemical bond between FA and polymer. X-ray diffraction and differential scanning calorimetry analyses indicated that microencapsulation led to drug amorphization. FA-loaded microparticles showed a slower dissolution rate than pure drug. The chosen formulation demonstrated higher in vitro cytoprotection, anti-inflammatory and immunomodulatory potential and also improved in vivo anti-platelet effect These results support an experimental basis for the use of FA spray-dried microparticles as a feasible oral drug delivery carrier for the controlled release of FA and improved cytoprotective and anti-platelet effects. (C) 2016 Elsevier B.V. All rights reserved.
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