Synthesis and characterization of Co3O4 ultra-nanosheets and Co3O4 ultra-nanosheet-Ni(OH)2 as non-enzymatic electrochemical sensors for glucose detection

The present study examines the synthesis of Co3O4 ultra-nanosheets (Co3O4 UNSs) and Co3O4 ultra-nanosheet-Ni(OH)(2) (Co3O4 UNS-Ni(OH)(2)) via solvothermal process and their application as non-enzymatic electrochemical sensors for glucose detection: X-ray diffraction and transmission electron microscopy results confirmed the Co3O4 UNS deposition on Ni(OH)(2) surface. The presence of Co3O4 UNSs on Ni (OH) (2) surface improved the sensitivity of glucose detection, from the increase of glucose oxidation peak current at the Co3O4-Ni(OH)(2)/glassy carbon electrode (current density: 2000 mu A.cm(-2)), compared to the Co3O4 UNSs. These results confirmed that Ni(OH)(2) on glassy carbon electrode is a sensitive material for glucose detection, moreover the Co3O4 UNSs can increase the interaction and detection of glucose due to their high surface area. The estimated limit of detection (S/N = 3) and limit of quantification (S/N = 10) of the linear segment (5-40 mu M) are 1.08 mu M and 3.60 mu M respectively. The reproducibility experiments confirmed the feasibility of Co3O4 UNS-Ni(OH)(2) for the quantitative detection of certain concentration ranges of glucose. (C) 2015 Elsevier B.V. All rights reserved.