Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 68, Issue -, Pages 482-493Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.06.023
Keywords
Graphene; Microfluidics; Global health; Immune-device; Bioelectronics
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Funding
- Drug Applied Research Center, Tabriz University of Medical Sciences
- Nano Technology Center, Urmia University
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Graphene is a 2-D carbon nanomaterial with many distinctive properties that are electrochemically beneficial, such as large surface-to-volume ratio, lowered power usage, high conductivity and electron mobility. Graphene-based electrochemical immune-devices have recently gained much importance for detecting antigens and biomarkers responsible for cancer diagnosis. This review describes fabrication and chemical modification of the surfaces of graphene for immunesensing applications. We also present a comprehensive overview of current developments and key issues in the determination of some biological molecules with particular emphasis on evaluating the models. This review focuses mostly on new developments in the last 5 years in development of chip architecture and integration, different sensing modes that can be used in conjunction with microfluidics, and new applications that have emerged or have been demonstrated; it also aims to point out where future research can be directed to in these areas. (C) 2016 Elsevier B.V. All rights reserved.
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