Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 68, Issue -, Pages 551-556Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.06.021
Keywords
Hydroxyapatite (HA); Biomimetic; Carboxymethyl cellulose (CMC); Phase transformation; Lysozyme adsorption
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Funding
- National Natural Science Foundation of China [81271639]
- Beijing Natural Science Foundation [7162023]
- Research Fund for the Doctoral Program of Higher Education of China [20131107120023]
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Because of its superior biocompatibility, hydroxyapatite (HA) has been widely exploited as a promising vehicle to deliver a broad range of therapeutics in a variety of biological systems. Herein, we report a biomimetic process to prepare nano-sized, colloidal stable HA with needle-like morphology by using carboxymethyl cellulose (CMC) as the template. It was revealed that the needle-like HA was transformed from the spherical amorphous calcium phosphate (ACP) nanoparticles after a 14-day period of aging under ambient conditions. The needle-like HA/CMC exhibited an ultra-high lysozyme adsorption capacity up to 930-940 mg/g. Moreover, a sustained and pH-sensitive release of adsorbed lysozyme from HA/CMC was evidenced. Therefore, our biomimetic needle like HA/CMC nanoparticles hold great potential in serving as an efficient carrier for the delivery and controlled release of lysozyme. (C) 2016 Elsevier B.V. All rights reserved.
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