Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 65, Issue -, Pages 338-344Publisher
ELSEVIER
DOI: 10.1016/j.msec.2016.04.039
Keywords
Bending; Compressive; Hardness; Hydroxyapatite; Chitosan; Magnetite nano-particles
Categories
Funding
- Research Committee of Shiraz University [86-GR-ENG-62]
- Delta Dental
- National Science Foundation (NSF) [EEC-1160483, ECCS-1351533, CMMI-1363485]
- AFOSR [FA9550-12-1-0225]
- Marquette University Strategic Innovation Fund
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Chitosan (CS), hydroxyapatite (HA), and magnetite (Fe3O4) have been broadly employed for bone treatment applications. Having a hybrid biomaterial composed of the aforementioned constituents not only accumulates the useful characteristics of each component, but also provides outstanding composite properties. In the present research, mechanical properties of pure CS, CS/HA, CS/HA/magnetite, and CS/magnetite were evaluated by the measurements of bending strength, elastic modulus, compressive strength and hardness values. Moreover, the morphology of the bending fracture surfaces were characterized using a scanning electron microscope (SEM) and an image analyzer. Studies were also conducted to examine the biological response of the human Mesenchymal Stem Cells (hMSCs) on different composites. We conclude that, although all of these composites possess in vitro biocompatibility, adding hydroxyapatite and magnetite to the chitosan matrix can noticeably enhance the mechanical properties of the pure chitosan. (C) 2016 Elsevier B.V. All rights reserved.
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