Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 59, Issue -, Pages 1016-1024Publisher
ELSEVIER
DOI: 10.1016/j.msec.2015.10.037
Keywords
Hesperetin; Cyclodextrin; Binding behaviors; Solubilization; Stability
Categories
Funding
- Natural Science Foundation of China [21162042, 21562048]
- Education Department of Yunnan Province [ZD2014010]
- Innovative Team of Yunnan Minzu University
- Key Laboratory of Resource Clean Conversion in Ethnic Regions of Yunnan
- China Scholarship Council [201408535034]
- Excellent Young Talents of Yunnan University
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The inclusion complexation behavior, characterization and binding ability of hesperetin with p-cyclodextrin and its derivatives were investigated in both the solution and solid state by means of XRD, DSC, SEM, H-1 and 20 NMR and'UV vis spectroscopy. The results showed that the water solubility and stability of hesperetin were obviously increased in the inclusion complex with cydodextrins. This satisfactory water solubility and high stability of the hesperetin/CD complexes will be potentially useful for their application as herbal medicines or healthcare products. (C) 2016 Published by Elsevier B.V.
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