Nasal septum lesions causing diagnostic difficulty: Case report

Benign nasal septal tumors are rare and exhibit various histologic features. It is necessary to treat them based on a plan that considers the prognosis, functionality, and esthetics. We report two similar and rare cases of nasal septal tumors with different diagnoses that we treated with nasal septal tumor resection. Eosinophilic angiocentric disease was the most likely diagnosis of one of the two cases, but it was not confirmed by the IgG4:IgG ratio. The other case was diagnosed as extranodal Rosai-Dorfman disease based on its histological features. The histological appearance of nasal septal tumors varies widely; therefore, a careful diagnosis based on both clinical and pathological perspectives is required.

Automated summary

Benign nasal septal tumors are rare and have different histologic features. Treatment should consider prognosis, functionality, and esthetics. We present two similar cases with different diagnoses of nasal septal tumors, both treated with resection. One case was likely eosinophilic angiocentric disease, but not confirmed by IgG4:IgG ratio. The other case was diagnosed as extranodal Rosai-Dorfman disease based on histological features. Careful diagnosis based on clinical and pathological perspectives is necessary due to the wide variation in histological appearance of nasal septal tumors.