Journal
CHEMICAL BIOLOGY & DRUG DESIGN
Volume 86, Issue 4, Pages 776-782Publisher
WILEY-BLACKWELL
DOI: 10.1111/cbdd.12550
Keywords
AChE inhibition; Alzheimer's disease; derivatives; icariin; synthesis
Funding
- Science and Technology Support Program of Sichuan Province [2014SZ0071]
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A new series of icariin derivatives were synthesized and evaluated for their in vitro acetylcholinesterase (AChE) inhibitory activity. Most of the tested compounds exhibited high AChE inhibition and low toxicity, and among which compounds 1, 2, and 10 were the most potent (IC50=71.52 +/- 22.43, 8.28 +/- 1.45, 5.830 +/- 1.78nm, respectively).
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