3.8 Review

Models of neuroinflammation for the assessment of kappa-opioid receptor ligands

Journal

Publisher

PYATIGORSKII MEDIKO-FARMATSEVTICHESKII INST
DOI: 10.19163/2307-9266-2023-11-1-4-18

Keywords

neuroinflammation; experimental models; neuroimmune processes; microglia; kappa-opioid receptors; kappa-opioid agonists; lipopolysaccharide

Ask authors/readers for more resources

The study provides a summary of the current strategies used to evaluate the neuroinflammatory effects of kappa-opioid ligands in laboratory animals with induced neuroinflammation. Various experimental models of neuroinflammation were evaluated, and the strengths and limitations of each model were assessed to identify the most appropriate approach for investigating the relationship between neuroinflammation and kappa-opioid receptors.
The development of new drugs to combat neuroinflammation is highly relevant as it opens up possibilities for the treatment of a wide range of diseases, including Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia, depression, and others. Kappa-opioid agonists represent a promising class of compounds with a high potential to be used in the treatment of neurological conditions accompanied by neuroinflammation. The aim of the study was to provide a summary of the current strategies employed to evaluate the neurotropic anti-inflammatory effects of kappa-opioid ligands in laboratory animals with induced neuroinflammation. Materials and methods. The databases, such as Google Scholar, PubMed, ScienceDirect, Scopus, e-Library were used as search tools. The search comprised the following keywords and phrases in Russian and English: kappa opioids + neuroinflammation; kappa opioid receptors + neuroinflammation; neuroinflammation models; neuroinflammation models in rats, neuroinflammation models in mice. 148 relevant articles were found, 122 were included in this review. Results. Various experimental models of neuroinflammation, including chemically-induced and bacterial endotoxin-induced neuroinflammation, as well as traumatic and genetic models in mice and rats were evaluated. In addition, the strengths and limitations of each model were critically assessed to identify the most appropriate and reliable approach for investigating the relationship between neuroinflammation and signaling pathways associated with kappa-opioid receptors. Conclusion. The neurotropic anti-inflammatory activity of kappa-opioid ligands have been comprehensively described. The review discusses both experimental models where the effects of kappa-opioid agonists have been investigated, as well as the models where the anti-inflammatory properties of kappa-opioid agonists have not been studied yet.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

3.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available