Journal
MATERIALS LETTERS
Volume 183, Issue -, Pages 101-104Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2016.07.044
Keywords
Bioinks; Biofabrication; 3D Bioprinting; Recombinant spider silk protein; Physical crosslinking; Spidroin
Funding
- Deutsche Forschungsgemeinschaft [SFB 840 TP A8]
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Hydrogels made of polyanionic recombinant spider silk proteins (spidroins) were prepared either in the presence or the absence of Dulbecco's Modified Eagle Medium (DMEM). Mono- and divalent cations present in DMEM severely affected the self-assembly process of the spidroins. Although the addition of DMEM had no apparent effect on secondary structure formation, there was a significant effect on the kinetics as well as on the hydrogel network; in the presence of DMEM, gelation occurred more rapidly. Additionally, the hydrogels were stiffer; however, the hydrogels were still shear-thinning. In summary, it can be concluded that there is a significant impact of ionic cross-linking on recombinant spidroin-based hydrogels. (C) 2016 Elsevier B.V. All rights reserved.
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