Journal
MATERIALS LETTERS
Volume 168, Issue -, Pages 56-61Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.matlet.2016.01.010
Keywords
Electrospinning; Cellulose nanofibers; Hydroxyapatite; Bone regeneration; Nanocomposites
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- National Research Foundation of Korea [22A20153813519] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A successful method for fabrication of electrospun hydroxyapatite (HAp) coated cellulose nanofiber scaffold (HAp/CMC) for tissue engineering is reported. The cellulose acetate nanofibers (CANFs) were deacetylated to produce cellulose nanofibers (CNFs) which were subsequently converted to sodium carboxy methyl cellulose (Na-CMC). The Na-CMC nanofibers mat was then coated with HAp for bone regeneration applications. The FTIR results confirmed conversion of CANFs to CNFs and CNFs to Na-CMC. HAp nanocrystal growth was observed in SEM images, with crystal becoming minute and numerous upon increasing HCO3- in the simulated body fluid (SBF) solution. The proliferation of osteoblastic MC3T3-E1 cells on HAp-coated CMC nanofiber mat was observed to increase with seeding time. The results confirm suitability of the HAp/CMC nanofiber mat for bone regeneration. (C) 2016 Elsevier B.V. All rights reserved.
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