Journal
SYNOPEN
Volume 7, Issue 2, Pages 258-266Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-2091-7934
Keywords
multicomponent reactions; Doebner reaction; Ugi reaction; peptidomimetics; pyrrolones; diastereoselectivity
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This study describes the synthesis of novel peptidomimetics containing a pyrrolone fragment by a tandem combination of Doebner and Ugi type multicomponent reactions. The synthesis was performed at temperatures ranging from 25 to 45 degrees C and exhibited controlled diastereoselectivity. In most cases, each diastereomer could be isolated separately using this method.
Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range from 25 to 45 degrees C. In most cases, the new method allowed each diastereomer to be isolated separately.
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