Multifunctional Fe3O4@WO3@mSiO2-APTES nanocarrier for targeted drug delivery and controllable release with microwave irradiation triggered by WO3

We constructed a novel WO3 interlayered Fe3O4@WO3@mSiO(2)-APTES core-shell structured drug nano carrier to investigate loading and controllable release properties of etoposide (VP16). This nanocomposite composed of mesoporous silica (mSiO(2)) shell with magnetic Fe3O4 core, WO3 interlayer. They possesses high surface area of 234.5 m(2)/g, provides large accessible pore volume of 0.14 cm(3)/g for adsorption of drug molecules, high magnetization saturation value of 40.54 mu mu/g for drug targeting under foreign magnetic fields, relatively higher reflection loss of 22.75 dB for controlled release by microwave triggered which was caused by WO3 interlayer. The VP16 release of over 85.69% under microwave discontinuous irradiation outclasses the 15.88% within 600 min only stirring release. This multifunctional material shows good performance for targeting delivery and WO3 microwave controlled release of anticancer drugs based on all the properties they possess. (C) 2016 Elsevier B.V. All rights reserved.