Journal
SA JOURNAL OF RADIOLOGY
Volume 27, Issue 1, Pages -Publisher
AOSIS
DOI: 10.4102/sajr.v27i1.2572
Keywords
galactorrhoea; hypothyroidism; isosexual precocious puberty; pituitary; ovarian mass; thyroid stimulating hormone (TSH); per vagina; Van Wyk Grumbach syndrome (VWGS)
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This case report discusses a rare condition known as Van Wyk Grumbach syndrome (VWGS), which involves isosexual precocious puberty with ovarian masses in long-standing juvenile hypothyroidism. The patient, a 4-year-old girl, was referred for imaging to determine the cause of non-traumatic bleeding per vagina. The antecedent history, clinical features, and thyroid function tests all supported a diagnosis of long-standing juvenile hypothyroidism, which had shown a clinical response to thyroxine replacement therapy.
Isosexual precocious puberty with ovarian masses in long-standing juvenile hypothyroidism is well described in the literature as Van Wyk Grumbach syndrome (VWGS). The present case reports this rare entity in a 4-year-old girl who was referred for imaging to evaluate the cause of non-traumatic bleeding per vagina. Antecedent history, clinical features and thyroid function tests were consistent with long-standing juvenile hypothyroidism with documented clinical response to thyroxine replacement therapy.
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