Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 63, Issue 3, Pages 187-194Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c14-00735
Keywords
Ophiopogon japonicus; Liriope spicata; steroidal glycoside; anti-inflammatory activity
Funding
- Major National Science and Technology Project of China for Significant New Drugs Development [2012ZX09102201-015]
- National Natural Science Foundations of China [81274004, 81473317]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education
- Postgraduate Innovation Project of Jiangsu Province, China [CX09B_285Z]
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Two new steroidal glycosides (1 and 2), together with 15 known compounds (3-17) were isolated from the fibrous roots of Ophiopogon japonicas, and three new steroidal glycosides (18-20), together with 14 known compounds (21-34) were isolated from the fibrous roots of Liriope spicata var. prolifera. The structures of the new compounds were elucidated on the basis of extensive one-dimensional (1D)- and 2D-NMR spectroscopic analyses and mass spectrometry. The isolated compounds were evaluated for their anti-inflammatory activity in vitro. Most of these steroidal glycosides showed significant inhibitory activity against neutrophil respiratory burst stimulated by phorbol myristate acetate.
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