Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 63, Issue 2, Pages 117-121Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c14-00538
Keywords
Allium sativum; cyclic sulfoxide; garlicnin K; tetrahydrothiophen derivative; M2 activated macrophage; anticancer activity
Funding
- Grants-in-Aid for Scientific Research [25293089] Funding Source: KAKEN
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Newly identified cyclic sulfoxides-garlicnins K-1 (1), K-2 (2), and H-1 (3)-were isolated from the acetone extracts of the bulbs of garlic, Allium sativum. Garlicnin Hi (3) demonstrated potential to suppress tumor cell proliferation by regulating macrophage activation. The structures of garlicnins K-1 and K-2, 3,4-dimethyl-5-allyl-tetrahydrothiophen-2-one-S-oxides, and the structure of garlicnin H-1, 3-carboxy-3-hydroxy-4-methyl-5-allylsulfoxide-tetrahydrothiophen-2-(ethane-1,2-diol)-S-oxide were characterized by spectroscopic analysis.
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