Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 63, Issue 1, Pages 33-37Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c14-00578
Keywords
Yanglingmycin; structural analogue; substituted cyclic azole; antibacterial activity
Funding
- National Key S&T Research Foundation of China [2010CB126105]
- National Natural Science Foundation of China [31371958, 21372185]
- Funds of Central Colleges Basic Scientific Research Operating Expenses [QN2011117]
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The synthesis of Yanglingmycin and its enantiomer, along with eighteen Yanglingmycin analogues is reported. The structures were confirmed mainly by analyses of NMR spectral data. Antibacterial activity assays showed that Yanglingmycin and some of its analogues exhibited significant antibacterial activities against two important agricultural pathogenic bacteria, Ralstonia solanacearum and Pseudomonas syringae pv. actinidiae, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 15.62 mu g/mL. The antibacterial activities exhibited by Yanglingmycin and its analogues are promising, suggesting potential in the development of compounds for novel bactericides.
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