Journal
MATERIALS CHEMISTRY AND PHYSICS
Volume 181, Issue -, Pages 227-233Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.matchemphys.2016.06.053
Keywords
Biomaterials; Chemical synthesis; Adsorption; Ceramics
Categories
Funding
- Program for National Natural Science Foundation of China [51172207, 51202219, 51372226]
- Zhejiang Provincial Natural Science Foundation of China [LY16E020013]
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To improve the fixations of the implant and implant-bone integration after joint arthroplasty from locally preventing inflammation and promoting the bone regeneration, we design a multifunctional biomaterial consisting of recombinant human bone morphogenetic protein 2 (rhBMP-2) and antibiotic loaded nanohydroxyapatite with an alginate/gelatin sticky gel. We investigate its role for the prevention of the inflammation and possibility of inducing a new bone growth along with its adhesive ability. The stickiness exists in the composite, which may help to fix itself on the bone fracture surface. The composite sustains the antibacterial effect and promotes the proliferation and differentiation of MG63 cells in vitro. In vivo experimentation also shows that the composite gel has a role for the reduction of inflammation. It enhances the formation of new bone and blood vessels compared to both the sole rhBMP-2 and non-rhBMP-2/antibiotic loaded composite gels. The multifunctional composite provides a promising material for the prosthetic and bone tissue regeneration. (C) 2016 Elsevier B.V. All rights reserved.
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