Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 63, Issue 6, Pages 481-484Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c14-00855
Keywords
Madhuca pasquieri; Sapotaceae; lindelofidine-1-hydroxymethyl pyrrolizidine
Funding
- National Research Foundation of Korea - Korean Government (MEST) [KRF-2012R1A1A2003547, 2012R1A2A2A06046921]
- National Research Foundation of Korea [2012R1A2A2A06046921] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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A novel pyrrolizidine alkaloids, madhumidine A (1), and two known alkaloids, lindelofidine benzoic acid ester (2) and minalobine B (3) were isolated from the leaves of Madhuca pasquieri (Dubard) H. J. LAM. The chemical structures of these alkaloids were established mainly by NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against lipopolysaccharide-induced nitric oxide production in macrophage RAW264.7 cell. In addition, the cytotoxic activity of all isolated compounds was tested against a panel of cancer cell lines.
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