Non-Newtonian blood flow with magnetic nanoparticles in a W-shaped stenosed arterial segment: A numerical study

Flow of blood, infused with magnetic nanoparticles, in a W-shaped stenosed human arterial segment is studied numerically using a realistic non-Newtonian blood rheology model. It is observed that the Newtonian model predicts less time to reach a steady state than the non-Newtonian blood rheology model. An increased drug retention time at the target site with an increase in nanoparticle concentration is predicted. Detailed simulations further reveal that the skin friction coefficient does not increase significantly with the increase in nanoparticle concentration. Hence, it is anticipated from our study that the infusion of drug-carrying nanoparticles in blood flow does not excessively enhance wall shear stress that may lead to arterial wall damage. An overall increase in heat transfer rates and wall shear stress at the stenosed section is seen with an increase in Reynolds number. The present study provides valuable information for designing computer-assisted drug delivery systems.

Automated summary

Numerical analysis of blood flow infused with magnetic nanoparticles in a W-shaped stenosed human arterial segment was performed using a realistic non-Newtonian blood rheology model. Results showed that the Newtonian model predicted a shorter time to reach steady state compared to the non-Newtonian model. It was also predicted that an increase in nanoparticle concentration would lead to increased drug retention time at the target site. This study provides valuable information for designing computer-assisted drug delivery systems.