Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 63, Issue 12, Pages 992-997Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c15-00497
Keywords
polysaccharide; hydroxyethylcellulose; polymeric prodrug; mechanochemical solid-state copolymerization; drug release; 5-fluorouracil
Ask authors/readers for more resources
Novel polymeric prodrugs were synthesized by mechanochemical solid-state copolymerization of hydroxyethylcellulose and the methacryloyloxy derivative of 5-fluorouracil (5-FU). Copolymerization was about 94% complete after 4h, and the polymeric prodrug was quantitatively obtained after 14h of reaction. The number average molecular weight (M-n) and polydispersity (H) of the polymeric prodrug were 39000 g/mol and 6.20, respectively. Mechanical fracturing of the polymer in a stainless steel twin-shell blender improved these properties (M-n=16000 g/mol and H=1.94). 5-FU was sustainably released from the polymeric prodrugs, and the rate was not affected by the molecular weight or molecular weight distribution of the prodrug under the experimental conditions used. These results suggest that novel polymeric prodrugs composed of a polysaccharide and a synthetic polymer can be fabricated by mechanochemical solid-state copolymerization under anaerobic conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available