Digitally enabled decentralised research: opportunities to improve the efficiency of clinical trials and observational studies

Editorial Material Biochemistry & Molecular Biology

Patient reported outcome assessment must be inclusive and equitable

Melanie J. Calvert et al.

NATURE MEDICINE (2022)

Article Medicine, General & Internal

Therapies for Long COVID in non-hospitalised individuals: from symptoms, patient-reported outcomes and immunology to targeted therapies (The TLC Study)

Shamil Haroon et al.

Summary: This study aims to evaluate the symptom burden and underlying pathophysiology of Long COVID syndromes in non-hospitalised individuals and evaluate potential therapies.

BMJ OPEN (2022)

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Article Medicine, General & Internal

Development and validation of the symptom burden questionnaire for long covid (SBQ-LC): Rasch analysis

Sarah E. Hughes et al.

Summary: This study described the development and validation of a novel patient reported outcome measure for symptom burden from long covid, called the Symptom Burden Questionnaire for Long Covid (SBQ-LC). The questionnaire consists of 17 independent scales and has promising psychometric properties. It can be used to evaluate the impact of interventions and inform best practices in clinical management.

BMJ-BRITISH MEDICAL JOURNAL (2022)

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Editorial Material Health Care Sciences & Services

Digital biomarkers: Convergence of digital health technologies and biomarkers

Srikanth Vasudevan et al.

Summary: The increasing digitization in healthcare has led to the development and adoption of Digital Health Technologies (DHT). The term 'digital biomarker' has been used to describe various measurements, and this study aims to align its meaning with established biomarker terminology and improve the assessment of scientific evidence for future digital biomarkers.

NPJ DIGITAL MEDICINE (2022)

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Review Medicine, Research & Experimental

Digitally Enabled, Patient-Centric Clinical Trials: Shifting the Drug Development Paradigm

Marissa F. Dockendorf et al.

Summary: The rapidly advancing field of digital health technologies has the potential to revolutionize the way clinical trials are conducted. Merck's digitally enabled clinical trial initiative aims to reduce patient burden, improve drug adherence, and enhance data collection for more effective drug development.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2021)

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Editorial Material Health Care Sciences & Services

Empowering clinical research in a decentralized world

Walter De Brouwer et al.

Summary: The COVID-19 pandemic has accelerated the use of digital health technologies in decentralized clinical trials, enabling remote real-time data acquisition and privacy protection. Technological applications under policies and regulations have expanded the scope and accelerated the pace of clinical research.

NPJ DIGITAL MEDICINE (2021)

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Editorial Material Medicine, General & Internal