Journal
JOURNAL OF COMPOSITES SCIENCE
Volume 7, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jcs7030104
Keywords
ligaments; 3D-printed scaffold; textile-engineered scaffold; functionalized graphene; PLA; composites
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This study proposes novel biodegradable and biocompatible scaffolds that match the mechanical characteristics of the native human ligament. The scaffolds showed high porosity, pore interconnectivity, and suitable pore size for ligament tissue ingrowth. The tailorable design and simplicity of manufacturing make these scaffolds suitable for ligament tissue engineering.
The development of scaffolds for tissue-engineered growth of the anterior cruciate ligament (ACL) is a promising approach to overcome the limitations of current solutions. This work proposes novel biodegradable and biocompatible scaffolds matching the mechanical characteristics of the native human ligament. Poly(L-lactic acid) (PLA) scaffolds reinforced with graphite nano-platelets (PLA+EG) as received, chemically functionalized (PLA+f-EG), or functionalized and decorated with silver nanoparticles [PLA+((f-EG)+Ag)], were fabricated by conventional braiding and using 3D-printing technology. The dimensions of both braided and 3D-printed scaffolds were finely controlled. The results showed that the scaffolds exhibited high porosity (>60%), pore interconnectivity, and pore size suitable for ligament tissue ingrowth, with no relevant differences between PLA and composite scaffolds. The wet state dynamic mechanical analysis at 37 degrees C revealed an increase in the storage modulus of the composite constructs, compared to neat PLA scaffolds. Either braided or 3D-printed scaffolds presented storage modulus values similar to those found in soft tissues. The tailorable design of the braided structures, as well as the reproducibility, the high speed, and the simplicity of 3D-printing allowed to obtain two different scaffolds suitable for ligament tissue engineering.
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