Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Four new 14(13 -> 12)-abeolanostane triterpenoids featuring extended pi-conjugated systems, kadcoccitanes E-H (1-4), were obtained from the stems of Kadsura coccinea through using a HPLC - UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E-H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 mu M. [GRAPHICS] .

Automated summary

Four new 14(13 -> 12)-abeolanostane triterpenoids, named kadcoccitanes E-H (1-4), were isolated from the stems of Kadsura coccinea. Their structures and configurations were determined through spectroscopic analysis and quantum chemical calculations. However, these compounds showed no cytotoxic activities against the tested human tumor cell lines at a concentration of 40 μM.