Synthesis, Spectroscopic and Thermal Characterization and Antioxidant Activities of Three Schiff Bases Derived from Aminophenol

The main objective of this work is synthesized three Schiff bases: (E)-2-(((2hydroxyphenyl)imino)methyl)-6-methoxyphenol (I), (E)-2-(((3-hydroxyphenyl) imino)-Methyl)-6-Methoxyphenol(II) and (e)-2-(((4-hydroxyphenyl)imino)methyl)-6-amethoxyphenol(III) derivative of 2-hydroxy-3-methoxybenzaldehyde and ortho/meta / para-aminophenol, their structures were confirmed by spectroscopic methods: UV-Vis, FTIR, (1H, 13C NMR). Firstly, a thermogravimetric analysis (TGA/DTG) study of the composite Schiff bases proved them to be thermally stable. Secondly, the study of the biological properties of the synthesized compounds allowed the evaluation of the antioxidant activity by conventional methods (scavenging of the DPPH radical, and bleaching of ss-carotene). The results demonstrated a variable degree of inhibitory effects on the growth of synthesized Schiff bases.

Automated summary

The main objective of this work is to synthesize three Schiff bases, and their structures were confirmed by spectroscopic methods. The synthesized compounds were proven to be thermally stable through a thermogravimetric analysis. The evaluation of the biological properties showed that the synthesized Schiff bases exhibited varying degrees of inhibitory effects on growth.