Journal
MARINE DRUGS
Volume 14, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/md14120220
Keywords
marine organisms; metabolic disorder; diabetes; microalgae; marine biotechnology; drug discovery
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Funding
- European Union 7th Framework Program PHARMASEA [312184]
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Diabetes is a chronic degenerative metabolic disease with high morbidity and mortality rates caused by its complications. In recent years, there has been a growing interest in looking for new bioactive compounds to treat this disease, including metabolites of marine origin. Several aquatic organisms have been screened to evaluate their possible anti-diabetes activities, such as bacteria, microalgae, macroalgae, seagrasses, sponges, corals, sea anemones, fish, salmon skin, a shark fusion protein as well as fish and shellfish wastes. Both in vitro and in vivo screenings have been used to test anti-hyperglycemic and anti-diabetic activities of marine organisms. This review summarizes recent discoveries in anti-diabetes properties of several marine organisms as well as marine wastes, existing patents and possible future research directions in this field.
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